منابع مشابه
Recent Advances in Solid-State Analysis of Pharmaceuticals
Current analytical techniques for characterizing solid-state pharmaceuticals include powder x-ray diffraction, differential scanning calorimetry, thermogravimetric analysis, infrared spectroscopy, Raman spectroscopy, electron microscopy and nuclear magnetic resonance. Powder x-ray diffraction and differential scanning calorimetry are mainstream techniques but they lack spatial resolution. Scann...
متن کاملLyophilization and development of solid protein pharmaceuticals.
Developing recombinant protein pharmaceuticals has proved to be very challenging because of both the complexity of protein production and purification, and the limited physical and chemical stability of proteins. To overcome the instability barrier, proteins often have to be made into solid forms to achieve an acceptable shelf life as pharmaceutical products. The most commonly used method for p...
متن کاملSolid-State NMR Investigation of Compaction Induced Amorphization of Crystalline Pharmaceuticals
Solid-state NMR (ssNMR) spectroscopy has shown its indispensable capability of elucidating atomic level structures and interactions in pharmaceutical studies [1-3]. In the past one decade, it has been utilized to investigate polymorphism of pharmaceutical crystalline compounds and the phase transformations during manufactural processing. These thermodynamic transitions of active pharmaceutical ...
متن کاملMethanol synthesis catalyst manufacturing using the green solid-state method
In this research study, methanol synthesis catalysts were manufactured with various mole ratios of metal carbonates (zinc, copper and aluminum carbonate) and ammonium hydrogen carbonate via a green solid-state method that employed a ball mill apparatus. Some parameters for the catalyst preparation, such as Al mole percent, Cu/Zn mole ratio, rotations milling speeds and aging time, were optimize...
متن کاملQuantifying the Structural Dynamics of Pharmaceuticals in the Glassy State.
Structural dynamics in the glassy state of two protic ionic liquids, carvedilol phosphate and procaine hydrochloride, were characterized from analysis of changes in the conductivity relaxation times during physical aging. The obtained relaxation times, having a magnitude exceeding feasible experimental time scales and thus not directly measurable, are consistent with published data from a metho...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: CrystEngComm
سال: 2019
ISSN: 1466-8033
DOI: 10.1039/c9ce90044f